Principle Microbiology

For a chemical compound To be an ideal chemotherapeutic agent used for treating microbial infections, it should have the following qualities:

(1)SELECTIVE TOXICITY :- The drug should demonstrate selective toxicity. This means that, at the optimum concentration, the drug should be toxic for the microorganism, but not for the host.

(2)ANTIMICROBIAL SPECTRUM :- The drug should be able to destroy or inhibit many kinds of pathocenic microorganisms. The larger the number of different microbial pathogenic soedes affected, the better.

(3)NO SIDE EFFECTS :- The drug should noç produce undesirable side effects, such as allergic reactions, nerve damage, irt of the kidney or damaging blood cells etc.

(4)NO KILLING EFFECT ON NORMAL FLORA :- The drug should not eliminate the normal icrobiat flora that inhabits the intestinal tract or other areas of the body. The normal flora also play an important role in preventing pathogens form growing.

(5)NO INACTiVATION :- If the drug is given orally, it should not be inactivated by stomach acids, and it should be absorbed into The body from the intestinal tract. If it is administrated by injection it shoud be inactivated by binding to blood proteins.

(6)NO DEVELOPMENT OF DRUG REStSTANCE :- The drug should inhibit microorganisms in such a way as to prevent the development of drug—resistant forms of pathogens.